NALAWADE et al: INCLUSION COMPLEXES OF VALSARTAN FOR IMPROVEMENT IN SOLUBILITY
نویسندگان
چکیده
This study presents improvement in solubility and dissolution rate of valsartan (VAL) using β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HP-βCD). Formation and characterization of solid inclusion complexes were investigated by DSC, FTIR, SEM, HNMR and in-vitro dissolution studies. Preparation method influenced physical properties of binary mixtures. Inclusion complexes obtained by co-evaporation method showed higher in vitro drug dissolution rates.
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